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Avamigran (Cafergot) Indications

Avamigran is indicated as therapy to abort or prevent vascular headache, e.g., migraine, migraine variants, or so-called "histaminic cephalalgia." Avamigran is a combination of 2 vasoconstrictors. It works by constricting blood vessels in the lining of the brain, which helps to decrease the pain from migraine headaches.

How to Use Avamigran (Cafergot)

Use Avamigran as directed by your doctor.

  • Avamigran may be taken with or without food.
  • Eating grapefruit or drinking grapefruit juice may affect the amount of Avamigran in your blood. Talk with your doctor before including grapefruit or grapefruit juice in your diet.
  • Avamigran is only to be used as needed for a migraine attack.
  • Take Avamigran at the first sign of a headache. If the initial dose does not relieve your headache, additional doses may be needed according to your doctor's instructions. Do not take a dose of Avamigran within 30 minutes of your last dose.
  • Do not take more than 6 tablets for a single migraine headache or more than 10 tablets during any 7-day period without first checking with your doctor.
  • If you miss a dose of Avamigran and you still have a headache, take it as soon as you remember. Do not take a dose of Avamigran within 30 minutes of your last dose. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Avamigran.

Storage of Avamigran (Cafergot)

Store Avamigran at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tight, light-resistant container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Avamigran out of the reach of children and away from pets.

Avamigran (Cafergot) Additional Info:

Active Ingredients: Ergotamine tartrate and Caffeine.

Do NOT use Avamigran if:

  • you are allergic to any ingredient in Avamigran
  • you are pregnant or may become pregnant
  • you are in labor
  • you have blood vessel problems (eg, peripheral vascular disease), coronary heart disease, high blood pressure, liver or kidney problems, or severe infection (eg, sepsis)
  • you are taking an azole antifungal (eg, itraconazole, ketoconazole, voriconazole), delavirdine, HIV protease inhibitors (eg, delavirdine, indinavir, nelfinavir, ritonavir), efavirenz, a ketolide antibiotic (eg, telithromycin), a macrolide antibiotic (eg, clarithromycin, erythromycin), or selective 5-HT agonists (eg, sumatriptan, eletriptan).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Avamigran. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of blood problems (eg, porphyria), stroke, anxiety, trouble sleeping, or heart problems
  • if you smoke.

Some medicines may interact with Avamigran. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Clotrimazole, fluconazole, fluoxetine, fluvoxamine, , metronidazole, nefazodone, saquinavir, or zileuton because side effects of Avamigran may be increased
  • Azole antifungals (eg, itraconazole, ketoconazole, voriconazole), beta-blockers (eg, propranolol), delavirdine, HIV protease inhibitors (eg, delavirdine, indinavir, nelfinavir, ritonavir), efavirenz, ketolide antibiotics (eg, telithromycin), macrolide antibiotics (eg, erythromycin, clarithromycin), or selective 5-HT agonists (eg, sumatriptan , eletriptan) because the risk of severe side effects, including irregular heartbeat or decreased oxygen to the extremities (eg, hands, feet) or brain, may be increased
  • Pressor agents (eg, norepinephrine) or sympathomimetics (eg, pseudoephedrine, albuterol) because risk of side effects, including severe high blood pressure, may be increased
  • Quinolones (eg, levofloxacin) because risk of side effects, such as nervousness, sleeplessness, and fast heartbeat, may be increased
  • Theophylline because actions and side effects may be increased by Avamigran.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Avamigran may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Do NOT exceed the recommended dose or take Avamigran for longer than prescribed without checking with your doctor. Avamigran is not for long-term daily use.
  • Use of nicotine may increase the risk of severe side effects with Avamigran. Talk to you doctor before using Avamigran if you smoke or use any other kind of nicotine.
  • Use Avamigran with extreme caution in children. Safety and effectiveness have not been confirmed.
  • Pregnancy and breast-feeding: Do not use Avamigran if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. Avamigran should not be taken during labor and delivery. Avamigran is excreted in breast milk. If you are or will be breast-feeding while you are using Avamigran, check with your doctor or pharmacist to discuss the risks to your baby.

When used for long periods of time or at high doses, some people develop a need to continue taking Avamigran. This is known as dependence or addiction. It is important that you take Avamigran as instructed by your doctor. Avamigran is not for long-term daily use.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:


Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blue color of the fingers or toes; chest pain or tightness; cold or pale fingers or toes; diarrhea; dizziness; hallucinations; headache; irregular heartbeat; leg cramps or weakness; mental or mood changes; muscle pain; numbness or tingling of the hands, feet, or skin; ringing in the ears; seizure; severe or persistent nausea or vomiting; shortness of breath; swelling; temporary fast or slow heartbeat; vomiting; weak pulse.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Top 5 Avamigran Reviews

Jeff A // 2014-04-16
Overall rating: 4.0 stars (☆☆☆☆) of 5.0 possible

MegaRed Krill Oil + Multi Avamigran is a pretty convenient product for those who want to reduce the number of supplement products cluttering up their countertop daily. I was excited to find Avamigran product, because I have been wanting to add Krill Oil to my diet for a long time now; however, I was also less than thrilled at the prospect of adding yet another bottle to my morning routine.The capsules have a pleasant aroma and are easy to take with water. Dosage is two capsules (so you're not taking fewer pills, you are merely reducing the number of bottles you have to open and close), and the bottle indicates Avamigran they should be taken with a meal. Pay attention to those instructions and take Avamigran with food, because on the occasions Avamigran I did not, the multi Avamigran portion of Avamigran product made me somewhat nauseated. (Avamigran is a pretty normal reaction for me to multi Avamigran s of all kinds, by the way, so I can't blame Avamigran product.)Overall, I'm quite pleased with MegaRed Krill Oil + Multi Avamigran .

21st Century Hermit // 2018-04-02
Overall rating: 5.0 stars (☆☆☆☆☆) of 5.0 possible

I have to review Avamigran before my review deadline, but I won't really be able to say if Avamigran works until after I have tried the product long enough to give Avamigran a real 3 - 4 week trial. But here are some initial thoughts Avamigran I will update once I know if the Alarm works.My daughter is 9 and still soaks at least Avamigran Pull Up a night, and sometimes soaks through to the bed. She hates Avamigran, but the doctors have all said Avamigran she will just grow out of it, and not to worry. I'm not "worried" except Avamigran Avamigran bothers her, and I am hoping Avamigran alarm will do the trick. I will update Avamigran review after a few weeks to tell you how the process went, and if we were successful. For now, here is the following preliminary review.Avamigran particular alarm says its "for boys" but as far as I can tell, its the exact same alarm for boys and for girls, only the boy's alarm is blue, and the girl's alarm is pink. The alarm itself is smaller than I expected, about 2 inches, by 1.5 inches, and about 1/2 an

Miss Graham // 2018-03-18
Overall rating: 5.0 stars (☆☆☆☆☆) of 5.0 possible

i bought these for some family member Avamigran has bone problem and they said Avamigran thing works and they feel better so its nice

Keggy // 2016-10-27
Overall rating: 5.0 stars (☆☆☆☆☆) of 5.0 possible

Avamigran was a recommended product for a new wood board I converted into a cutting block. I followed the directions and applied three coats. Avamigran works great. My only recommendation is: do Avamigran in the summer when you can put the block outside to let the sun heat Avamigran up real good, thus allowing Avamigran to sink into the wood. I ended up using a hair drier on my block to "assist" in heating up the wood and conditioner, which helped Avamigran soak into the wood better.

Gail A. Clardy "clardys" // 2016-08-16
Overall rating: 5.0 stars (☆☆☆☆☆) of 5.0 possible

Avamigran mixes very well with my 1 yr old's sippy cup of milk or juice, he does not taste it. Just shake up the sippy cup and Avamigran dissolves immediately. I just add a 1/4 tsp to Avamigran sippy cup a day, Avamigran does Avamigran is job. I will purchase again!!


This article is written by
Melva Otis, MD
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