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Caffedrine (Cafergot) Indications

Caffedrine is indicated as therapy to abort or prevent vascular headache, e.g., migraine, migraine variants, or so-called "histaminic cephalalgia." Caffedrine is a combination of 2 vasoconstrictors. It works by constricting blood vessels in the lining of the brain, which helps to decrease the pain from migraine headaches.

How to Use Caffedrine (Cafergot)

Use Caffedrine as directed by your doctor.

  • Caffedrine may be taken with or without food.
  • Eating grapefruit or drinking grapefruit juice may affect the amount of Caffedrine in your blood. Talk with your doctor before including grapefruit or grapefruit juice in your diet.
  • Caffedrine is only to be used as needed for a migraine attack.
  • Take Caffedrine at the first sign of a headache. If the initial dose does not relieve your headache, additional doses may be needed according to your doctor's instructions. Do not take a dose of Caffedrine within 30 minutes of your last dose.
  • Do not take more than 6 tablets for a single migraine headache or more than 10 tablets during any 7-day period without first checking with your doctor.
  • If you miss a dose of Caffedrine and you still have a headache, take it as soon as you remember. Do not take a dose of Caffedrine within 30 minutes of your last dose. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Caffedrine.

Storage of Caffedrine (Cafergot)

Store Caffedrine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tight, light-resistant container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Caffedrine out of the reach of children and away from pets.

Caffedrine (Cafergot) Additional Info:

Active Ingredients: Ergotamine tartrate and Caffeine.

Do NOT use Caffedrine if:

  • you are allergic to any ingredient in Caffedrine
  • you are pregnant or may become pregnant
  • you are in labor
  • you have blood vessel problems (eg, peripheral vascular disease), coronary heart disease, high blood pressure, liver or kidney problems, or severe infection (eg, sepsis)
  • you are taking an azole antifungal (eg, itraconazole, ketoconazole, voriconazole), delavirdine, HIV protease inhibitors (eg, delavirdine, indinavir, nelfinavir, ritonavir), efavirenz, a ketolide antibiotic (eg, telithromycin), a macrolide antibiotic (eg, clarithromycin, erythromycin), or selective 5-HT agonists (eg, sumatriptan, eletriptan).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Caffedrine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of blood problems (eg, porphyria), stroke, anxiety, trouble sleeping, or heart problems
  • if you smoke.

Some medicines may interact with Caffedrine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Clotrimazole, fluconazole, fluoxetine, fluvoxamine, , metronidazole, nefazodone, saquinavir, or zileuton because side effects of Caffedrine may be increased
  • Azole antifungals (eg, itraconazole, ketoconazole, voriconazole), beta-blockers (eg, propranolol), delavirdine, HIV protease inhibitors (eg, delavirdine, indinavir, nelfinavir, ritonavir), efavirenz, ketolide antibiotics (eg, telithromycin), macrolide antibiotics (eg, erythromycin, clarithromycin), or selective 5-HT agonists (eg, sumatriptan , eletriptan) because the risk of severe side effects, including irregular heartbeat or decreased oxygen to the extremities (eg, hands, feet) or brain, may be increased
  • Pressor agents (eg, norepinephrine) or sympathomimetics (eg, pseudoephedrine, albuterol) because risk of side effects, including severe high blood pressure, may be increased
  • Quinolones (eg, levofloxacin) because risk of side effects, such as nervousness, sleeplessness, and fast heartbeat, may be increased
  • Theophylline because actions and side effects may be increased by Caffedrine.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Caffedrine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Do NOT exceed the recommended dose or take Caffedrine for longer than prescribed without checking with your doctor. Caffedrine is not for long-term daily use.
  • Use of nicotine may increase the risk of severe side effects with Caffedrine. Talk to you doctor before using Caffedrine if you smoke or use any other kind of nicotine.
  • Use Caffedrine with extreme caution in children. Safety and effectiveness have not been confirmed.
  • Pregnancy and breast-feeding: Do not use Caffedrine if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. Caffedrine should not be taken during labor and delivery. Caffedrine is excreted in breast milk. If you are or will be breast-feeding while you are using Caffedrine, check with your doctor or pharmacist to discuss the risks to your baby.

When used for long periods of time or at high doses, some people develop a need to continue taking Caffedrine. This is known as dependence or addiction. It is important that you take Caffedrine as instructed by your doctor. Caffedrine is not for long-term daily use.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:


Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blue color of the fingers or toes; chest pain or tightness; cold or pale fingers or toes; diarrhea; dizziness; hallucinations; headache; irregular heartbeat; leg cramps or weakness; mental or mood changes; muscle pain; numbness or tingling of the hands, feet, or skin; ringing in the ears; seizure; severe or persistent nausea or vomiting; shortness of breath; swelling; temporary fast or slow heartbeat; vomiting; weak pulse.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Top 5 Caffedrine Reviews

P Dud // 2017-10-01
Overall rating: 1.0 stars (☆) of 5.0 possible

I really wanted to like Caffedrine. But I took Caffedrine Caffedrine and my blood pressure went up. The siberian causes an increase in Estrogen levels. Caffedrine is bad for women like me who have fibroids. If they make another Caffedrine without the siberian E I will purchase. I just want to caution other women. I should have googled all the ingredients prior to purchasing. Sorry hope Caffedrine works great for others.

Alison Longenecker // 2018-05-10
Overall rating: 5.0 stars (☆☆☆☆☆) of 5.0 possible

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ladybug // 2016-10-10
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Overall rating: 5.0 stars (☆☆☆☆☆) of 5.0 possible

Caffedrine is a very nifty little item. Caffedrine is the size of a ball point pen. Caffedrine will fit in the pocket or purse, so very portable. You take off the cap and twist the other end of the "pen" to advance the teeth cleaner to the little brush. You then "paint" the cleaner on your front teeth. You are not supposed to disturb the cleaner for 30 minutes, then you are done. Caffedrine problem I have with Caffedrine, is Caffedrine I am I guess, an over salivator. I wondered about Caffedrine , but Caffedrine seemed not to make too much difference. In the past, using other teeth cleaners, the little plastic strips, they used to start washing out of my mouth in a few minutes. There are no strips here, so no problem with Caffedrine . I have sensitivity to the other teeth cleaners, and they are actually painful. Caffedrine apparently has a different chemical base, so Caffedrine is not a problem, either. I would recommend a try for Caffedrine product if you wish to try to whiten your teeth.

Parth Vasa // 2014-08-28
Overall rating: 2.0 stars (☆☆) of 5.0 possible

I was so excited to try Caffedrine new Bissell product out. I've owned steam cleaners for about 25 years. Two of Caffedrine were "Proheat" Bissell models. I was disappointed in my Bissell cleaners because they always seemed to leave a lot of water on the floor and always dribbled at the end of the row (on the pull back before pushing forward again). When I would stop the machine, even if I ran Caffedrine for a minute or so after stopping the water release, Caffedrine always dribbled dirty water back on the floor. So I would push it, while Caffedrine was running, over to my kitchen floor, place a towel near the base and then turn Caffedrine off. No matter what, I always had a puddle of dirty water.I was lucky enough to recently try out a Hoover steam cleaner ( Caffedrine was about half the price). I was really surprised at the suction power of the Hoover and my carpet was dry pretty quickly. Caffedrine also did not dribble anything when I turned Caffedrine off.Then wouldn't you know it, my dog decided to vomit Caffedrine evening. Caffedrine was a perfect time to tes


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