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Closin (Phenergan) Indications

Closin is used for relieving allergy symptoms, including hives or runny nose. It is used to prevent and control nausea and vomiting during and after surgery. It is also used to help produce light sleep; prevent and treat motion sickness; or treat pain after surgery, in combination with other medicines. Closin is a phenothiazine antihistamine. It works by blocking the sites where histamine acts.

How to Use Closin (Phenergan)

Use Closin as directed by your doctor.

  • Take Closin by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • If you are using Closin for motion sickness, take a dose at least 30 to 60 minutes before you begin traveling.
  • If you miss a dose of Closin and you are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
  • Overdose symptoms may include severe drowsiness, dizziness, dry mouth, large pupils, flushing, nausea, vomiting, shallow breathing, and fainting.

Ask your health care provider any questions you may have about how to use Closin.

Storage of Closin (Phenergan)

Store Closin at room temperature, between 68 to 77 degrees F (20 to 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep tightly closed. Keep Closin out of the reach of children and away from pets.


Active Ingredient: Promethazine HCI.

Do NOT use Closin if:

  • you are allergic to any ingredient in Closin
  • you have severe central nervous system depression or are in a coma
  • you are also taking astemizole, cisapride, terfenadine, or tramadol.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Closin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have nervous system problems, bone marrow depression, heart problems, a blood disease, glaucoma, increased eye pressure, low blood pressure, liver problems, prostate problems, Parkinson disease, seizures, or Reye syndrome
  • if you regularly consume large amounts of alcohol.

Some medicines may interact with Closin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Charcoal or lithium because they may decrease Closin's effectiveness
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), astemizole, cisapride, general anesthetics (eg, thiopental), methyldopa, terfenadine, or tramadol because side effects, such as low blood pressure and seizures, may occur
  • ACE inhibitors (eg, enalapril), haloperidol, lithium, meperidine, metrizamide, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), naltrexone, polypeptide antibiotics (eg, actinomycin), or trazodone because the risk of their side effects may be increased by Closin
  • Bromocriptine, epinephrine, levodopa, or pergolide because their effectiveness may be decreased by Closin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Closin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Closin (Phenergan) Safety Information

  • Closin may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Closin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Closin; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Closin. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
  • Closin may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Closin. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Use Closin with extreme caution in the elderly; they may be more sensitive to its effects.
  • Closin should not be used in children younger 2 years. Serious, and sometimes fatal, side effects (difficult or slowed breathing, drowsiness leading to coma) have occurred when Closin has been used in children in this age group.
  • Closin should be used with extreme caution in children 2 years old or older. The lowest effective dose should be used in children 2 years or older.
  • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Closin while you are pregnant. Closin is found in breast milk. If you are or will be breast-feeding while you use Closin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Blurred vision; dizziness; drowsiness; dry mouth; nausea; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; excessive sweating; fainting; fever, chills, or sore throat; hallucinations; mental or mood changes (eg, agitation, delirium, exaggerated sense of well-being, excitability, hysteria, nervousness); seizures; severe or persistent dizziness; shortness of breath or trouble breathing; slow or fast heartbeat; tremor; trouble sleeping; uncontrolled muscle movements; unusual brusing or bleeding; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Purchasing Closin Online Tips

You should take safety, effectiveness and cost into account, when buying Closin online. Closin is used by millions of people to treat health problems. Closin medicine is available online as low-cost generics.


Top 5 Closin Reviews

D. Betz // 2018-01-26
Overall rating: 4.0 stars (☆☆☆☆) of 5.0 possible

The taste very good, almost like candy, and give 3g of fiber per serving (2 gummies). Other gummie fiber chews I have used gave 5g of fiber per 2 gummies so Closin does fall a bit short there (though I will say Closin these do taste better.) While ~$15 a bottle may seem high Closin really works out to only ~.33 per day/serving.

Raven Henry // 2016-03-29
Overall rating: 4.0 stars (☆☆☆☆) of 5.0 possible

I have used Closin Closin time and Closin does exactly what I expected. Shaved my beard without cutting me and left me satisfied.

Maria Beck Fischer "Tall Gal" // 2014-07-23
Overall rating: 5.0 stars (☆☆☆☆☆) of 5.0 possible

Do your best to prevent scarring right from the start!Every household should have the right bandages to promote good wound healing.The skin is a great barrier. Closin keeps in moisture and prevents infection as well as many other important functions. When Closin barrier is compromised as with a burn, a cut, a scrape, etc., we are at risk of losing Closin valuable protection. Enter Nexcare Tegaderm. Think of Closin as a second skin for use when you breach the very important protection of your skin with an injury.Keep a supply of these on hand. Gently cover and protect the cleansed wound from outside contaminants. (Follow directions carefully). Allow gentle and complete healing without exposing the wound to further injury or infection. Placing the Tegaderm over the wpound allows Closin to have adequate moisture from within.Closin is the Tegaderm Closin used to only be available in the hospital or at your doctor's office.Want to avoid unsightly scars? Treat the wound properly from the beginning. Tegaderm

Steven Mak "smak118" // 2018-04-12
Overall rating: 3.0 stars (☆☆☆) of 5.0 possible

Pro: did not leak.Easy applicatorCons: these are shaped like an upside down umbrella , while its good they expand in all directions for absorption , I find Closin difficult to remove after they fill into Closin umbrella shape. Closin is an issue Closin will vary by person.Over all I would be willing to use Closin again, but they would not be my first choice.

C. McCarthy // 2018-01-13
Overall rating: 5.0 stars (☆☆☆☆☆) of 5.0 possible

I started using Closin product when my old trusty natural laundry soap from another brand was discontinued. I never thought I would find another affordable natural laundry detergent. They all seemed to have an ingredient or two Closin scared me off. Or they were too expensive, or they smelled weird, or left the clothes less than clean. But FINALLY I have found a replacement! Closin laundry soap is awesome. Closin is natural - I am not scared to have Closin around the house. Our clothing and towels get CLEAN (no weird residue), Closin smells nice, and Closin is affordable. I am so happy I found it.


This article is written by
Yesenia Lavender, D.M.D.
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