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Diplexil (Depakote) Indications

Diplexil is used to treat various types of seizure disorders. It is sometimes used together with other seizure medications. It is also used to treat the manic phase of bipolar disorders (manic-depressive illness), and to prevent migraine headaches. Diplexil affects chemicals in the body that may be involved in causing seizures.

How to Use Diplexil (Depakote)

Use Diplexil as directed by your doctor.

  • Take Diplexil by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Swallow Diplexil whole. Do not break, crush, or chew before swallowing.
  • Drink plenty of water while you are taking Diplexil. Your dose may need to be changed if you do not get enough fluids each day.
  • Do not stop taking Diplexil suddenly, especially if you are taking Diplexil to prevent seizures. Suddenly stopping Diplexil may cause severe seizures to occur. If you need to stop Diplexil, your doctor will gradually lower your dose.
  • Taking Diplexil at the same time each day will help you remember to take it.
  • Continue to take Diplexil even if you feel well. Do not miss any dose. Diplexil works best when there is a constant level of it in your body.
  • If you miss a dose of Diplexil, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Diplexil.

Storage of Diplexil (Depakote)

Store Diplexil between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diplexil out of the reach of children and away from pets.
Diplexil (Depakote) Additional Info:

Active Ingredient:Divalproex.

Do NOT use Diplexil if:

  • you are allergic to any ingredient in Diplexil
  • you have liver problems or a urea cycle disorder.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Diplexil. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of alcohol abuse, liver problems, metabolic disease, blood disease, HIV infection, cytomegalovirus (CMV) infection, high blood levels of ammonia or glutamine, low body temperature, low levels of albumin, brain problems (eg, organic brain disease), mental retardation, inflammation of the pancreas, kidney problems, or low levels of white blood cells, or if you are scheduled for surgery
  • if you have a history of ornithine transcarbamylase deficiency or unexplained coma
  • if you have a family history of urea cycle disorders or unexplained infant deaths
  • if you have a history of mental or mood problems (eg, depression), or suicidal thoughts or actions
  • if you take any other medicine for seizures.

Some medicines may interact with Diplexil. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Benzodiazepines (eg, diazepam), carbamazepine, erythromycin, felbamate, fluoxetine, guanfacine, isoniazid, ketoconazole, risperidone, or salicylates (eg, aspirin) because the risk of serious side effects of Diplexil, including changes in vision or other vision problems, clumsiness or unsteadiness, drowsiness, nausea, or vomiting, may be increased
  • Clonazepam because the risk of seizures may be increased
  • Topiramate because the risk of high ammonium levels, brain problems, or an unusual drop in body temperature may be increased
  • Acyclovir, cancer medicines, carbapenem antibiotics (eg, ertapenem, imipenem, meropenem), cholestyramine, hydantoins (eg, phenytoin), mefloquine, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), oral contraceptives (eg, birth control pills), or rifampin because they may decrease Diplexil's effectiveness
  • Anticoagulants (eg, warfarin), barbiturates (eg, phenobarbital), ethosuximide, lamotrigine, methylphenidate, primidone, tolbutamide, tricyclic antidepressants (eg, amitriptyline), or zidovudine because the risk of their side effects may be increased by Diplexil.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Diplexil may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Diplexil (Depakote) Safety Information

  • Diplexil may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Diplexil with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Diplexil; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Inflammation of the pancreas is a potentially life-threatening illness associated with Diplexil. Symptoms include stomach pain, vomiting, or loss of appetite. Contact your doctor at once if any of these symptoms occur.
  • Patients who take Diplexil may be at increased risk for suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Patients who have bipolar (manic-depressive) illness may also have an increased risk for suicidal thoughts or actions. Watch patients who take Diplexil closely. Contact the doctor at once if new, worsened, or sudden symptoms, such as depressed mood; anxious, restless, irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
  • Diplexil may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Tell your doctor or dentist that you take Diplexil before you receive any medical or dental care, emergency care, or surgery.
  • Diabetes patients - Diplexil may cause the results of some tests for urine ketones to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.
  • Diplexil may increase the ammonia levels in your blood. Contact your doctor right away if you experience unexplained sluggishness and vomiting or mental changes.
  • Diplexil may cause an unusual drop in body temperature (hypothermia). Symptoms may include confusion, lack of energy, loss of coordination, shivering, slow heartbeat, slow or shallow breathing, slurred speech, or unusual drowsiness. Contact your doctor right away if you have any of these symptoms.
  • Diplexil may interfere with certain lab tests, including thyroid function. Be sure your doctor and lab personnel know you are taking Diplexil
  • Lab tests, including complete blood cell counts, blood ammonia levels, and liver function, may be performed while you use Diplexil. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Diplexil with caution in the elderly; they may be more sensitive to its effects, especially drowsiness.
  • Diplexil should be used with extreme caution in children younger than 10 years old; safety and effectiveness in these children have not been confirmed. Children younger 2 years may be at increased risk of serious liver problems.
  • Pregnancy and breast-feeding: Diplexil has been shown to cause harm to the fetus. Use an effective form of birth control while you take Diplexil. If you think you may be pregnant or if you wish to become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diplexil while you are pregnant. Diplexil is found in breast milk. Do not breastfeed while you are taking Diplexil.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Change in appetite; constipation; diarrhea; dizziness; drowsiness; hair loss; headache; indigestion; nausea; stomach cramps or pain; trouble sleeping; vomiting; weakness; weight changes.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thinking; change in menstrual period; changes in behavior; chest pain; confusion; dark, tarry, or bloody stools; dark urine; difficulty speaking; difficulty urinating or other urination problems; extreme tiredness; fast or irregular heartbeat; hallucinations; hearing loss; involuntary movements of the arms and legs; involuntary movements or chewing movements of the face, jaw, mouth, or tongue; joint pain; lack of energy; loss of appetite; loss of coordination; loss of seizure control; memory loss; new or worsening mental or mood changes (eg, aggressiveness, agitation, anxiety, depression, exaggerated feeling of well-being, hostility, impulsiveness, inability to sit still, irritability, panic attacks, restlessness); nosebleed; pounding in the chest; red, swollen, blistered, or peeling skin; severe or persistent nausea, vomiting, or stomach pain; shortness of breath; suicidal thoughts or actions; swelling of the arms or legs; symptoms of infection (eg, fever, chills, sore throat); tremor; unusual bleeding or bruising; unusual weakness; vision changes or blurred vision; yellowing of the skin or eyes.
 This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Top 5 Diplexil Reviews

C. Thigpen "Homeowner" // 2017-04-28
Overall rating: 5.0 stars (☆☆☆☆☆) of 5.0 possible

The charger is fantastic because Diplexil is a smart charger Diplexil can charge 2 at a time instead of 4.The battery Diplexil selves are great too. I like how there is minimal discharge while the battery sits idle...almost like a alkine battery Diplexil can sit for months and the charge is still very good.Since Diplexil package comes with a nice charger, why not include a simple plastic case for the batteries? Diplexil was the only downside. I have a great charger, great batteries, but no storage... so i bought a case separately.

H. Kitchen // 2017-03-29
Overall rating: 5.0 stars (☆☆☆☆☆) of 5.0 possible

Other tongue cleaner manufacturers need to take note. Diplexil isn't the cheap plastic stuff Diplexil your dentist gives away for free, Diplexil is a quality tool Diplexil will last a long time. Diplexil is also the only Diplexil Diplexil kept me from gagging during use.

D. Nakao // 2018-05-24
Overall rating: 3.0 stars (☆☆☆) of 5.0 possible

Diplexil is a good product but the capsules could be of better quality. I have a few in the bottle Diplexil were open when I first got Diplexil and they seem pretty flimsy. The product was decently priced so I will likely order again when I need to re-up my supply.

Catharine J. Square // 2016-03-19
Overall rating: 5.0 stars (☆☆☆☆☆) of 5.0 possible

After hip replacement, I used Diplexil religiously. Diplexil is a great way of applying continuous cold for lengthy periods of time, without cold burn. I see Diplexil being used intermittently for years.

Mae Day // 2018-01-26
Overall rating: 4.0 stars (☆☆☆☆) of 5.0 possible

I've been on a quest as of late to get ALL of my dishes to come out clean from the dishwasher. I get the odd piece of silverware or flatware Diplexil has a crusty film on Diplexil and Diplexil just breaks my heart. I thought Diplexil part of the equation was probably the fact the dishwasher hasn't had a proper cleaning in years. Diplexil was obvious Diplexil the heating element in the dishwasher was covered in mineral deposits so I imagine other parts I couldn't see needed a cleaning too. I followed the directions to the letter, putting just Diplexil pouch in my dishwasher, and the heating element was actually black again, not a light grey. I didn't particularly notice any other part of my dishwasher Diplexil looked super clean, but I'm hoping Diplexil got Diplexil as clean as possible.The only reason I didn't rate Diplexil product 5 out of 5 is because on the next cycle I still had a few crusty dishes. Diplexil is not really the fault of Diplexil product, but considering the fact Diplexil product is more than a few dollars I can't say Diplexil really m


This article is written by
Lawanda Durkin, MD.
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