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Topinmate (Topamax) Indications

Topinmate is used for treating seizures in certain patients. It may be used alone or with other medicines. It is also used to prevent migraine headaches. Topinmate is an anticonvulsant that is also effective for preventing migraine headaches. It affects several chemicals in the brain that help to reduce seizure activity and prevent migraine headaches from occurring.

How to Use Topinmate (Topamax)

Use Topinmate as directed by your doctor.

  • Take Topinmate by mouth with or without food.
  • Drink plenty of fluids while taking Topinmate to prevent kidney stones from forming.
  • Swallow Topinmate whole. Do not crush, break, or chew before swallowing.
  • Do not suddenly stop taking Topinmate. Suddenly stopping Topinmate may cause seizures to occur more often. If you need to stop Topinmate, your doctor will gradually lower your dose.
  • If you miss a dose of Topinmate, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Topinmate.

Storage of Topinmate (Topamax)

Store Topinmate at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, light, and moisture. Do not store in the bathroom. Keep Topinmate out of the reach of children and away from pets.
Topinmate (Topamax) Additional Info:

Active Ingredient:Topiramate.

Do NOT use Topinmate if:

  • you are allergic to any ingredient in Topinmate
  • you are taking a carbonic anhydrase inhibitor (eg, acetazolamide).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Topinmate. Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver or kidney problems, kidney stones, osteoporosis (weak bones), or metabolic problems, you drink alcohol regularly, or you are on a ketogenic diet
  • if you have diarrhea, lung or breathing problems, or low bicarbonate levels in the blood, or you will be having surgery
  • if you have a history of status epilepticus (continuous seizure activity or a series of seizures without a full return to consciousness)
  • if you have a history of mental or mood problems, or suicidal thoughts or actions.

Some medicines may interact with Topinmate. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticholinergics (eg, benztropine), carbonic anhydrase inhibitors (eg, acetazolamide), haloperidol, or tricyclic antidepressants (eg, nortriptyline) because the risk of decreased sweating may be increased
  • Valproic acid because a serious side effect with symptoms of confusion, lethargy, and vomiting may occur
  • Metformin or pioglitazone because blood glucose control may be altered; monitor your blood sugar carefully if you use Topinmate with metformin or pioglitazone
  • Hydrochlorothiazide because it may increase the risk of Topinmate's side effects
  • Carbamazepine or hydantoins (eg, phenytoin) because they may decrease Topinmate's effectiveness
  • Amitriptyline because the risk of its side effects may be increased by Topinmate
  • Lithium because Topinmate may have an effect on lithium blood levels
  • Hormonal birth control (eg, birth control pills) or risperidone because their effectiveness may be decreased by Topinmate.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Topinmate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Topinmate (Topamax) Safety Information

  • Topinmate may cause drowsiness, dizziness, confusion, or trouble concentrating. These effects may be worse if you take it with alcohol or certain medicines. Use Topinmate with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Topinmate; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Topinmate may reduce sweating, which could raise body temperature, especially in children. This risk is greater in hot weather and/or during vigorous exercise. Drink plenty of fluids. Dress lightly while in hot climates or when exercising. Check carefully for signs of decreased sweating. If this occurs, promptly seek cooler or air-conditioned shelter and/or stop exercising. Seek medical attention right away if you have unexplained fever, or if you have mental or mood changes, headache, or dizziness.
  • Tell your doctor or dentist that you take Topinmate before you receive any medical or dental care, emergency care, or surgery.
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using Topinmate. To prevent pregnancy, use an extra form of birth control (eg, condoms).
  • Lab tests, including serum bicarbonate levels, may be performed while you use Topinmate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Topinmate with caution in the elderly; they may be more sensitive to its effects.
  • Caution is advised when using Topinmate in children; they may be more sensitive to its effects, especially decreased sweating and decreased bicarbonate levels.
  • Topinmate may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they take Topinmate.
  • Topinmate should be used with extreme caution in children for migraines and in children  younger than 2 years old for seizures; safety and effectiveness in these children have not been confirmed.
  • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Topinmate while you are pregnant. Topinmate is found in breast milk. If you are or will be breast-feeding while you use Topinmate, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; decreased sweating; diarrhea; dizziness; drowsiness; dry mouth; flu-like symptoms; headache; loss of appetite; nausea; nervousness or anxiety; numbness or tingling of the skin; runny nose; sore throat; stomach pain or upset; taste changes; tiredness; trouble sleeping; weight loss.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; blurred vision; bone pain; chest pain; confusion; decreased coordination; depression; double vision or other vision changes; eye pain; irregular heartbeat; loss of consciousness; memory problems; menstrual changes; mental or mood changes; muscle or joint pain, cramps, or weakness; rapid, shallow breathing; red, swollen, blistered, or peeling skin; ringing in the ears; severe or persistent loss of appetite; severe stomach, side, or back pain; significant weight loss; speech problems; stupor; suicidal thoughts or actions; tremor; trouble thinking, concentrating, or remembering things; trouble walking; unexplained fever; unusual bruising or bleeding; unusual eye movements; unusual tiredness.
 This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.



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Author

This article is written by
Yesenia Lavender, D.M.D.
Author has 2502 publications on getyourmedsonline.org